Diamino-C,N-diarylpyridine positional isomers as inhibitors of lysophosphatidic acid acyltransferase-beta

Feng Hong; David Hollenback; Jack W Singer; Peter Klein

doi:10.1016/j.bmcl.2005.07.055

Diamino-C,N-diarylpyridine positional isomers as inhibitors of lysophosphatidic acid acyltransferase-beta

Bioorg Med Chem Lett. 2005 Nov 1;15(21):4703-7. doi: 10.1016/j.bmcl.2005.07.055.

Authors

Feng Hong¹, David Hollenback, Jack W Singer, Peter Klein

Affiliation

¹ Cell Therapeutics, Inc., 201 Elliott Ave. W., Suite 400, Seattle, WA 98119, USA.

PMID: 16143520
DOI: 10.1016/j.bmcl.2005.07.055

Abstract

2,6-Diamino-4,N-diarylpyridines were identified as potent, isoform selective inhibitors of the enzymatic activity of lysophosphatidic acid acyltransferase-beta (LPAAT-beta).

MeSH terms

Acyltransferases / antagonists & inhibitors*
Enzyme Inhibitors / chemical synthesis*
Enzyme Inhibitors / pharmacology
Humans
Inhibitory Concentration 50
Isomerism
Protein Isoforms
Pyridines / chemical synthesis*
Pyridines / pharmacology
Structure-Activity Relationship

Substances

Enzyme Inhibitors
Protein Isoforms
Pyridines
Acyltransferases
2-acylglycerophosphate acyltransferase